Books like The Nature of Drugs

This recommendation, I’ll admit, takes as its premise the hope that your partner on this walk might be Eli, the protagonist and narrator of The Beaut’, who—if I know him—probably snuck in his first read of the Huxley some time between the single day that he is remembering and the day he decided to tell us about it.

The question was, was there ever an edition of The Doors of Perception that wasn’t coupled with its customary companion, Heaven and Hell? Turns out there was, making this a mere 38-page volume of charmingly recollected mind expansion, and the next best thing to being there, which you kind of would be on your walk.

Kay Parley is a remarkable woman. Her book takes readers through her amazing life and the diverse experiences she encountered in an effort to make sense of her family history of psychiatric illness, her own institutionalization, and later her role as a psychiatric nurse and psychedelic guide. Against contemporary medical advice, Parley took LSD in Saskatchewan with Frances Huxley (Aldous’ nephew), and in this book, she explains how it gave her insights into her own excursions into madness and how to be a gentle guiding force for others who experienced disorientation, whether through illness or through mind-altering drugs.

This editorial team has worked tirelessly to promote informed discussions about psychedelic plant medicines. Peyote is one of their many published books that takes seriously the need to consider issues of Indigenous reciprocity, gender inclusion, cultural context, and environmental sustainability in the world of psychedelics. Psychedelic justice is not simply about consuming plant medicines but involves a reciprocal set of relationships that honour a long and often disturbing history of cultural appropriation and psychedelic tourism.

Anthropological fieldwork is not restricted to isolated indigenous people in remote areas. Anthropologists study scientists in university research labs. Langlitz did a remarkable feat: He immersed himself in the research activities of two laboratories studying psychedelic effects on humans and animals. Through this participation in everyday work, he delineated contextual sociological and psychological factors of what made it possible for researchers to be allowed to give healthy human subjects and patients with psychiatric problems mind-altering drugs in the lab and what motivates researchers to go into these frontier areas of research. LSD, psilocybin, and ayahuasca are studied again scientifically. What made that possible? Langlitz gives answers.

I was deeply impressed by how Psychiatry Under the Influence combines medical history, clinical knowledge, and investigative journalism about pervasive institutional conflicts of interest in medicine.

In Whitaker’s and Cosgrove’s case study of “institutional corruption” they trace the development over time of an alignment of the psychiatric profession’s “guild interests” in turf maximization and scientific legitimation with drug companies’ drive to market a widening array of drugs massively profitable drugs.

It is a fascinating illustration of the medicalization of life resulting from what I would call the “commercial construction of disease.”

Particularly eye-opening was the role of the American Psychiatric Association in constructing pseudo-scientific diagnostic categories of psychoses, panics, anxieties, depressive states, and the like for drug companies to capitalize on—and concealing, distorting, and fabricating research results that facilitate mass overprescribing of potentially harm-causing drugs.

Two pharmacists sit in a Boston courtroom accused of murder. The weapon: a fungus. The death count: 100 and rising. These facts set the stage for a true-crime thriller by investigative journalist Jason Dearen, and it has the makings of a horror movie. There’s scientific hubris, sketchy ethics, a cover-up, and a monster, too: a slimy, sticky, fungal mold that infected patients and began eating their brains alive. It’s riveting, packed with information about how fungal spores managed to contaminate a medical supply chain, and frankly hard to put down. I have done my share of forensic research, and never have I encountered killer fungus before; I consider this an unmissable book.

This is the first of Dervla’s Detective Cormac Reilly books - and what a wonderful start to a new series.

Here is a book as dark and unpredictable as the early spring weather in Galway. Cormac springs to life, fully formed as a complex, honest policeman, uncompromising and determined to solve a case that has re-emerged after haunting him for over twenty years.

Back then he rescued a little boy and his sister from terrible squalor and abuse. Now grown up, that boy has apparently committed suicide and his missing sister has returned claiming he was murdered and accusing the police of a cover up.

Add to this, Cormac’s own problems with a new posting in Galway, a hostile squad of detectives and a relationship he’s frantically trying to hold on to. A wonderful, complex, engrossing book.

I find Angell’s The Truth About the Drug Companies extremely valuable for teaching students about how the pharmaceutical industry translates high profits into power resources to protect and increase those profits over time.

The former New England Journal of Medicine editor exposed how drug companies enlist politicians, the FDA, and medical academia for their cause. And armies of lawyers to extend monopoly marketing rights for years.

It was my first introduction to how they spend more on marketing than research, much of that on “copy-cat” drugs of dubious superiority to ones with expired patents.

As a tax (and high drug price) payer, I was disturbed to learn how they use government funds for basic research and then rig and spin their reporting of clinical studies to inflate their products’ therapeutic value and underplay their risks. 

This account of the early years of Vertex Pharmaceuticals, from its inception as a scrappy start-up to its early work in HIV, is a must-read classic for anyone interested in how science turns into new drugs. Barry Werth’s journalistic play-by-play is a cinematic, true-to-life picture of the strategic decisions, real-world challenges, and larger-than-life personalities that underlie modern drug development. His riveting follow-up, The Antidote, continues the saga by taking readers through Vertex’s pathbreaking work to transform the care of patients with hepatitis C and cystic fibrosis.

A best-seller in the UK, it never garnered the attention it deserved in the US. As a trained physician, Goldacre explains why doctors cannot trust the information concerning prescription drugs that is made available to them, and why this should concern every patient. The incentives motivating drug regulators constitute a big part of the problem, but the actual conduct of clinical trials comes in for intensive scrutiny as well. The rigors of double-blinded trials are useless if owners of the data can hide whatever outcomes they don’t like. His chapter on how to bend a clinical trial has become a classic.