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In my younger days, as the son of a medical professor and a public health nurse, I was more interested in healing society than patients. But my political interests and research agenda as a professor of political science ultimately led back to medicine. I found that profit-maximizing market competition in health care failed miserably to promote value in therapeutics and economize on society’s scarce resources. I became aware of the neglect of public health to prevent disease for vulnerable groups in society and save money as well as lives. Pervasive and enduring economic conflicts of interest in the medical-industrial complex bear primary responsibility for severe deficits in quality, equality, and economy in American health care.
I find Angell’sThe Truth About the Drug Companies extremely valuable for teaching students about how the pharmaceutical industry translates high profits into power resources to protect and increase those profits over time.
The former New England Journal of Medicine editor exposed how drug companies enlist politicians, the FDA, and medical academia for their cause. And armies of lawyers to extend monopoly marketing rights for years.
It was my first introduction to how they spend more on marketing than research, much of that on “copy-cat” drugs of dubious superiority to ones with expired patents.
As a tax (and high drug price) payer, I was disturbed to learn how they use government funds for basic research and then rig and spin their reporting of clinical studies to inflate their products’ therapeutic value and underplay their risks.
During her two decades at The New England Journal of Medicine, Dr. Marcia Angell had a front-row seat on the appalling spectacle of the pharmaceutical industry. She watched drug companies stray from their original mission of discovering and manufacturing useful drugs and instead become vast marketing machines with unprecedented control over their own fortunes. She saw them gain nearly limitless influence over medical research, education, and how doctors do their jobs. She sympathized as the American public, particularly the elderly, struggled and increasingly failed to meet spiraling prescription drug prices. Now, in this bold, hard-hitting new book, Dr. Angell exposes…
It is April 1st, 2038. Day 60 of China's blockade of the rebel island of Taiwan.
The US government has agreed to provide Taiwan with a weapons system so advanced that it can disrupt the balance of power in the region. But what pilot would be crazy enough to run…
In my younger days, as the son of a medical professor and a public health nurse, I was more interested in healing society than patients. But my political interests and research agenda as a professor of political science ultimately led back to medicine. I found that profit-maximizing market competition in health care failed miserably to promote value in therapeutics and economize on society’s scarce resources. I became aware of the neglect of public health to prevent disease for vulnerable groups in society and save money as well as lives. Pervasive and enduring economic conflicts of interest in the medical-industrial complex bear primary responsibility for severe deficits in quality, equality, and economy in American health care.
Kassirer, also like Angell a highly respected physician and former editor of the New England Journal of Medicine, first opened my eyes to how extensively drug companies use their vast wealth to turn physicians into promoters and middlemen.
I knew about the small and not-so-small gifts, speaking fees, travel junkets, and the like to individual doctors and “key opinion leaders” of the profession, but not about the “institutional conflicts of interest” gladly entered into by specialty medical societies heavily dependent on drug money for their events and activities such as scientific meetings, journal publishing, clinical practice recommendations, and, not least “continuing medical education” required by law for license maintenance.
Although Kassirer, also like Angell, proposed reforms, from what I know about conditions today, not much has changed, so On the Takeremains an indispensable window into corrupted medicine.
We all know that doctors accept gifts from drug companies, ranging from pens and coffee mugs to free vacations at luxurious resorts. But as the former Editor-in-Chief of The New England Journal of Medicine reveals in this shocking expose, these innocuous-seeming gifts are just the tip of an iceberg that is distorting the practice of medicine and jeopardizing the health of millions of Americans today. In On the Take, Dr. Jerome Kassirer offers an unsettling look at the pervasive payoffs that physicians take from big drug companies and other medical suppliers, arguing that the billion-dollar onslaught of industry money has…
In my younger days, as the son of a medical professor and a public health nurse, I was more interested in healing society than patients. But my political interests and research agenda as a professor of political science ultimately led back to medicine. I found that profit-maximizing market competition in health care failed miserably to promote value in therapeutics and economize on society’s scarce resources. I became aware of the neglect of public health to prevent disease for vulnerable groups in society and save money as well as lives. Pervasive and enduring economic conflicts of interest in the medical-industrial complex bear primary responsibility for severe deficits in quality, equality, and economy in American health care.
I was deeply impressed by how Psychiatry Under the Influence combines medical history, clinical knowledge, and investigative journalism about pervasive institutional conflicts of interest in medicine.
In Whitaker’s and Cosgrove’s case study of “institutional corruption” they trace the development over time of an alignment of the psychiatric profession’s “guild interests” in turf maximization and scientific legitimation with drug companies’ drive to market a widening array of drugs massively profitable drugs.
It is a fascinating illustration of the medicalization of life resulting from what I would call the “commercial construction of disease.”
Particularly eye-opening was the role of the American Psychiatric Association in constructing pseudo-scientific diagnostic categories of psychoses, panics, anxieties, depressive states, and the like for drug companies to capitalize on—and concealing, distorting, and fabricating research results that facilitate mass overprescribing of potentially harm-causing drugs.
Psychiatry Under the Influence investigates the actions and practices of the American Psychiatric Association and academic psychiatry in the United States, and presents it as a case study of institutional corruption.
A Duke with rigid opinions, a Lady whose beliefs conflict with his, a long disputed parcel of land, a conniving neighbour, a desperate collaboration, a failure of trust, a love found despite it all.
Alexander Cavendish, Duke of Ravensworth, returned from war to find that his father and brother had…
In my younger days, as the son of a medical professor and a public health nurse, I was more interested in healing society than patients. But my political interests and research agenda as a professor of political science ultimately led back to medicine. I found that profit-maximizing market competition in health care failed miserably to promote value in therapeutics and economize on society’s scarce resources. I became aware of the neglect of public health to prevent disease for vulnerable groups in society and save money as well as lives. Pervasive and enduring economic conflicts of interest in the medical-industrial complex bear primary responsibility for severe deficits in quality, equality, and economy in American health care.
If you think that medical journals published by respected medical societies are full of good science, think again.
For me, Abramson’s Sickeningnailed the case for a conclusion that the net effect of the many hundreds of medical journals published here and around the world is to subtract from the sum of human medical knowledge.
Abramson, as an expert witness in criminal and civil cases against drug companies, draws in part on subpoenaed documents to expose how medical science, as part of the entire medical-industrial complex, is corrupted from start to finish by the drug industry’s funding of most clinical trials, their control over the data analysis, and even their ghost-writing of articles submitted to journals.
New and disturbing was the withholding of clinical trials’ raw data from journals’ peer reviewers. Instead, they get biased summaries bearing drug manufacturers’ fingerprints.
The inside story of how Big Pharma’s relentless pursuit of ever-higher profits corrupts medical knowledge—misleading doctors, misdirecting American health care, and harming our health.
The United States spends an excess $1.5 trillion annually on health care compared to other wealthy countries—yet the amount of time that Americans live in good health ranks a lowly 68th in the world. At the heart of the problem is Big Pharma, which funds most clinical trials and therefore controls the research agenda, withholds the real data from those trials as corporate secrets, and shapes most of the information relied upon by health care professionals.…
Frank S. David, MD, PhD leads the biopharma consulting firm Pharmagellan, where he advises drug companies and investors on R&D and business strategy. He is also an academic researcher on strategy, regulation, and policy in the drug industry; a member of the Harvard-MIT Center for Regulatory Science; and a former blogger at Forbes.com.
This account of the early years of Vertex Pharmaceuticals, from its inception as a scrappy start-up to its early work in HIV, is a must-read classic for anyone interested in how science turns into new drugs. Barry Werth’s journalistic play-by-play is a cinematic, true-to-life picture of the strategic decisions, real-world challenges, and larger-than-life personalities that underlie modern drug development. His riveting follow-up, The Antidote, continues the saga by taking readers through Vertex’s pathbreaking work to transform the care of patients with hepatitis C and cystic fibrosis.
I am an economist who came to realize that the marketplace of ideas was a political doctrine, and not an empirical description of how we came to know what we think we know. Science has never functioned in the same manner across centuries; it was only during my lifetime that it became recast as a subset of market reality. I have spent a fair amount of effort exploring how economics sought to attain the status of a science; but now the tables have turned. It is now scientists who are trained to become first and foremost market actors, finally elevating the political dominance of the economists.
A best-seller in the UK, it never garnered the attention it deserved in the US. As a trained physician, Goldacre explains why doctors cannot trust the information concerning prescription drugs that is made available to them, and why this should concern every patient. The incentives motivating drug regulators constitute a big part of the problem, but the actual conduct of clinical trials comes in for intensive scrutiny as well. The rigors of double-blinded trials are useless if owners of the data can hide whatever outcomes they don’t like. His chapter on how to bend a clinical trial has become a classic.
"Smart, funny, clear, unflinching: Ben Goldacre is my hero." ―Mary Roach, author of Stiff, Spook, and Bonk
We like to imagine that medicine is based on evidence and the results of fair testing and clinical trials. In reality, those tests and trials are often profoundly flawed. We like to imagine that doctors who write prescriptions for everything from antidepressants to cancer drugs to heart medication are familiar with the research literature about these drugs, when in reality much of the research is hidden from them by drug companies. We like to imagine that doctors are impartially educated, when in reality…
The Duke's Christmas Redemption
by
Arietta Richmond,
A Duke who has rejected love, a Lady who dreams of a love match, an arranged marriage, a house full of secrets, a most unneighborly neighbor, a plot to destroy reputations, an unexpected love that redeems it all.
Lady Charlotte Wyndham, given in an arranged marriage to a man she…
I am peculiar. Really. I’m an autistic, non-binary, PhD historian who writes mystery novels (The Framed Women of Ardemore House, The Dead Come to Stay) and weird non-fiction books (Mr. Humble and Dr. Butcher and The Intermediaries). But I also love to read, and among my friends are folks like Deanna Wraybourn (Killers of a Certain Age) and Chuck Wendig (Staircase in the Woods), Mary Roach (Stiff) and Deborah Blum (Poisoner’s Handbook). I wanted to share their work, too. That’s why I started the Peculiar Book Club YouTube and podcast: to be a home for authors and readers of the quirky, quizzical, curious, and bizarre. If you’re weird, you’re family.
Two pharmacists sit in a Boston courtroom accused of murder. The weapon: a fungus. The death count: 100 and rising. These facts set the stage for a true-crime thriller by investigative journalist Jason Dearen, and it has the makings of a horror movie. There’s scientific hubris, sketchy ethics, a cover-up, and a monster, too: a slimy, sticky, fungal mold that infected patients and began eating their brains alive. It’s riveting, packed with information about how fungal spores managed to contaminate a medical supply chain, and frankly hard to put down. I have done my share of forensic research, and never have I encountered killer fungus before; I consider this an unmissable book.
An award-winning investigative journalist's horrifying true crime story of America's deadliest drug contamination outbreak and the greed and deception that fueled it.
Two pharmacists sit in a Boston courtroom accused of murder. The weapon: the fungus Exserohilum rostratum. The death count: 100 and rising. Kill Shot is the story of their hubris and fraud, discovered by a team of medical detectives who raced against the clock to hunt the killers and the fungal meningitis they'd unleashed.
"Bloodthirsty" is how doctors described the fungal microbe that contaminated thousands of drug vials produced by the New England Compounding Center (NECC). Though NECC…
I write historical crime fiction, and my latest novel is set in a hospital, a real place, now closed. The South London Hospital for Women and Children (1912–1985) was set up by pioneering suffragists and women surgeons Maud Chadburn and Eleanor Davies-Colley (the first woman admitted to the Royal College of Surgeons) and I recreate the now almost-forgotten hospital in my book. Events take place in 1946 when wartime trauma still impacts upon a society exhausted by conflict, and my book choices also reflect this.
Like Green for Danger, this is a more classic mystery novel, though it is also a dystopian fiction.
The ‘hospital’ in which it is set is a facility for the elderly, who, denied access to antibiotics, wait there until, through accident or nature, they contract an infection and are allowed to die. Yet much of the novel takes place years earlier in South Africa and England, before the antibiotic crisis when the main character meets the love of her life. How we have progressed from today’s society to the society described in the book is gradually revealed, as is the narrator’s part in it. There are also mysterious happenings in the facility.
This is a vividly told tale set in an all too believable near future with restricted access to life-saving drugs. I admire the clever conceit and the intricate interweaving of past and present and was caught up…
Swinging from South Africa to England: one woman's hunt for her birth mother in an all-too-believable near future in which an antibiotic crisis has decimated the population. A prescient, thrilling debut.
'Combines the excitement of a medical thriller a la Michael Crichton with sensitive characterisation and social insight in a timely debut novel all the more remarkable for being conceived and written before the current pandemic' Guardian
'STUNNING and terrifying ... The Waiting Rooms wrenches your heart in every way possible, but written with such humanity and emotion' Miranda Dickinson
'Chillingly close to reality, this gripping thriller brims with authenticity…
Two facts about me as a reader: I like books that deal with difficult issues, and I like reading a lot of them. There’s something about watching teens, for whom everything feels new, deal with the toughest stuff imaginable and come out the other side. I love a protagonist who has been through the wringer. Some people call these stories dark or morbid. I prefer to think of them as hopeful. My own writing history is as diverse as my reading habits. I’ve published in poetry, romance, and criticism, but these days I’m all about YA, like the politically-charged thriller I’m querying or my queer New Orleans ghost story, The Women of Dauphine.
Thrillers! At a time when the world feels so perilous, what could be more satisfying than a high-stakes story that’s fully resolved by the last page? Only one that’s also a triumphant revenge fantasy.
Delilah is sick of feeling scared. When she retaliates against her tyrannical stepfather and he winds up dead, it would be the perfect crime–if not for a hidden camera planted by her creepy classmate. Logan believes he and Delilah are meant to be together, and he’s not above using blackmail to keep her around. Told in dual POV between Delilah and the eerily calm Logan, The Obsessionis fast-paced, riveting, and, if you’re new to the thriller world, an A+ introduction to the genre.
A fast-paced teen revenge-thriller from the author of Dial A for Aunties, The Obsession will keep readers on the edge of their seats until the very end. Boy Meets Girl. Boy Stalks Girl. Girl Gets Revenge. Logan thinks he and Delilah are meant to be. Delilah doesn't know who Logan is. Logan believes no one knows Delilah like him. He makes sure of it by learning everything he can by watching her through a hidden camera. Some might call him a stalker. Logan prefers to be called "romantic". Delilah is keeping secrets though, deadly ones. There's so much more to…
This book follows the journey of a writer in search of wisdom as he narrates encounters with 12 distinguished American men over 80, including Paul Volcker, the former head of the Federal Reserve, and Denton Cooley, the world’s most famous heart surgeon.
In these and other intimate conversations, the book…
I’m a Canadian writer born in Northern Ireland. My first book, A Nice Place to Die, introduced Northern Ireland detective DS Ryan McBride. In 2019, A Nice Place to Die won the RWA Daphne du Maurier Award for Mainstream Mystery and Suspense, was shortlisted in the Crime Writers of Canada Awards in 2021, and was a 2023 Silver Falchion Award finalist. As for my choices, each of these fabulous, atmospheric mysteries has richly drawn settings inhabited by characters the reader comes to care deeply about. This brings a book alive for me — each has a wonderful, compelling cast of characters and a clever, complex plot.
This is the first of Dervla’s Detective Cormac Reilly books - and what a wonderful start to a new series.
Here is a book as dark and unpredictable as the early spring weather in Galway. Cormac springs to life, fully formed as a complex, honest policeman, uncompromising and determined to solve a case that has re-emerged after haunting him for over twenty years.
Back then he rescued a little boy and his sister from terrible squalor and abuse. Now grown up, that boy has apparently committed suicide and his missing sister has returned claiming he was murdered and accusing the police of a cover up.
Add to this, Cormac’s own problems with a new posting in Galway, a hostile squad of detectives and a relationship he’s frantically trying to hold on to. A wonderful, complex, engrossing book.
It's been twenty years since Cormac Reilly discovered the body of Hilaria Blake in her crumbling Georgian home. But he's never forgotten the two children she left behind...
When Aisling Conroy's boyfriend Jack is found in the freezing black waters of the river Corrib, the police tell her it was suicide. A surgical resident, she throws herself into study and work, trying to forget--until Jack's sister Maude shows up. Maude suspects foul play, and she is determined to prove it.
Cormac Reilly is the detective assigned with the re-investigation of a seemingly accidental overdose twenty years ago--the overdose of Jack…