Books like Holden, After and Before

In All That’s Left To Say, dual timelines braid threads of a mystery together in a way that allowed me to contrast Hannah then and now and wonder not just about the mystery Hannah’s trying to solve, but about how she became the master sleuth she thinks she needs to be to get answers.

This contrast, as much as the mystery, drew me into the story and had me turning pages every time we jumped between past and present. Of course, the enemies-to-friends-to-lovers romance also helped. How Lord imbued a single tie-straightening scene with more sexual tension than most kissing scenes might be the biggest mystery in this book.

If you already dislike the pharmaceutical industry for whatever reason, this book could certainly make your blood boil further.

In an effort to get a diverse perspective on Big Pharma, I made sure to check out a book with a contrary opinion, and this one fit the bill. I came away with a greater awareness of the industry’s impacts that are widespread globally, not locally.

William and his wife lost their baby in its last term and had to endure the torment of an induced stillbirth.

The same thing happened to a dear friend years ago so when I heard William as embarking on this brave endeavour to write about it, I was intrigued. The publisher, Little Toller Books, decided to create a space for William’s male voice in a publishing genre that is dominated by women’s.

The result is a heart-wrenching tale of grief as William clamours to contextualise the world he has been thrown into. William’s skill as a writer lies in his depiction of the indescribable. I’m sure there were months of soul searching and pen holding before he finally hit upon a way of converting his pain into the stunning prose. I am so grateful he did. And you will be too.

After my daughter died, I wrote her hundreds and hundreds of letters. Sometimes it felt like she was the only one who could understand me. Other times, as I struggled to put one foot in front of the other, living up to what my dead daughter might have wanted for me was what kept me going. I was still deep in my grief when I first read Song for Sarah, a memoir composed of D’Arcy’s letters to her own lost child. A dear friend asked me how I could possibly read about another mother’s grief when I was so lost in my own. The answer, simply, was that D’Arcy made me feel seen. 

This account of the early years of Vertex Pharmaceuticals, from its inception as a scrappy start-up to its early work in HIV, is a must-read classic for anyone interested in how science turns into new drugs. Barry Werth’s journalistic play-by-play is a cinematic, true-to-life picture of the strategic decisions, real-world challenges, and larger-than-life personalities that underlie modern drug development. His riveting follow-up, The Antidote, continues the saga by taking readers through Vertex’s pathbreaking work to transform the care of patients with hepatitis C and cystic fibrosis.

I find Angell’s The Truth About the Drug Companies extremely valuable for teaching students about how the pharmaceutical industry translates high profits into power resources to protect and increase those profits over time.

The former New England Journal of Medicine editor exposed how drug companies enlist politicians, the FDA, and medical academia for their cause. And armies of lawyers to extend monopoly marketing rights for years.

It was my first introduction to how they spend more on marketing than research, much of that on “copy-cat” drugs of dubious superiority to ones with expired patents.

As a tax (and high drug price) payer, I was disturbed to learn how they use government funds for basic research and then rig and spin their reporting of clinical studies to inflate their products’ therapeutic value and underplay their risks. 

Now, I understand most people would consider Six of Crows a “heist book,” but can I just say… Inej is a goddess.

Her backstory is truly heartbreakingly powerful and has stuck with me even years after finishing. I loved this duology so much that I got my mother and two sisters to read it, and could rave about it for hours. 

A best-seller in the UK, it never garnered the attention it deserved in the US. As a trained physician, Goldacre explains why doctors cannot trust the information concerning prescription drugs that is made available to them, and why this should concern every patient. The incentives motivating drug regulators constitute a big part of the problem, but the actual conduct of clinical trials comes in for intensive scrutiny as well. The rigors of double-blinded trials are useless if owners of the data can hide whatever outcomes they don’t like. His chapter on how to bend a clinical trial has become a classic.

This is the first of Dervla’s Detective Cormac Reilly books - and what a wonderful start to a new series.

Here is a book as dark and unpredictable as the early spring weather in Galway. Cormac springs to life, fully formed as a complex, honest policeman, uncompromising and determined to solve a case that has re-emerged after haunting him for over twenty years.

Back then he rescued a little boy and his sister from terrible squalor and abuse. Now grown up, that boy has apparently committed suicide and his missing sister has returned claiming he was murdered and accusing the police of a cover up.

Add to this, Cormac’s own problems with a new posting in Galway, a hostile squad of detectives and a relationship he’s frantically trying to hold on to. A wonderful, complex, engrossing book.

This is the first volume of lecture notes from the infamous Alexander (Sasha) Shulgin, “inventor” of MDMA “ecstasy or molly”. Sasha and his wife Ann are well known in the world of psychedelics for their publications based on Sasha’s incredible knowledge of chemistry, Ann’s capacity to integrate experiences, and their shared contributions to the world of psychedelia. This new book, with an introduction from Mariavittoria Mangini, is a ‘warts and all’ introduction to the chemistry of mind alteration. It is highly accessible, at times comical, and a fascinating opportunity to voyeuristically sit in on a series of Shulgin lectures that promises to pique your curiosity about our chemical lives.