Books like CRISPR'd — picked by fans

A Crack in Creation was the first mainstream book that conveyed the extraordinary potential and ethical peril of the new genome editing technology, CRISPR. And who better to write it than the scientist who co-developed the “genetic scissors”, Professor Jennifer Doudna (who won the Nobel Prize three years later).

The book is also notable for the candid manner in which Doudna discusses her own nightmares about the potential misuse of CRISPR – fears that erupted one year later in the ‘CRISPR babies’ scandal.

This book starts and ends with the story of Dr. Jiankui He, the infamous Chinese researcher responsible for the first CRISPR experiment resulting in genetically modified children.

It chronicles Dr. He’s “meteoric rise to fame” followed by his “dramatic fall from grace.”

In telling this story Kirksey, a cultural anthropologist, entertains the reader with details about interesting characters he meets and places he visits in his quest to both situate this debacle in relation to earlier efforts at genetic engineering and cell therapy in the United States and to confirm some of the contested details about what did or did not happen in China in the years leading up to this “first”.

Along the way, Kirksey lays bare salient facts about conflicts of interests among scientists, the corporate world’s vaunted pursuit of profit, and the ways in which nationalistic aspirations seed unhealthy competition.

Somewhat paradoxically, this treatise against genetic enhancement starts with the case of a deaf couple who want to have a deaf child.

This is a case I often discuss in exploring the difference between disease, disability, and diversity. Following on from this case description, Sandel asks, “Is it wrong to make a child deaf by design?” And what if the desired trait was not deafness but height, athletic prowess, health, or intelligence, and the aim was to gain a competitive advantage?

Would your answer be the same? In the pages that follow, Sandel builds a case against “reengineering our nature” grounded in an ethic of giftedness (i.e., a reverence for life as a gift).

He eschews the drive to mastery and insists that “[t]o appreciate children as gifts is to accept them as they come, not as objects of our design, or products of our will, or instruments of our… show more.

Many assert that “science is outpacing ethics.”

In my book I argue that this claim is false and disingenuous. Consider this one example. Forty years ago, Glover anticipated the myriad ways in which genetic and neuro technologies might “change the central framework of human life.”

In this prescient book, Glover anticipates the use of genetic engineering and advocates caution as well as gradualness. Avoiding the risk of irreversible disaster is a priority. Glover outlines the drawbacks of centralized decision-making as well as the problems with piecemeal, short-term decision-making.

He enjoins us to reflect on what sort of people there should be and what sort of future we should try to bring about. My own work focuses on what kind of world we want to live in and, as such, we are kindred spirits.

British author, broadcaster and zoologist Matthew Cobb has written several books about the history of DNA research.

As Gods (the book’s original UK title is The Genetic Age) is a fast-paced analysis of “the thrilling and terrifying” 50-year history of genetic engineering and the rise of the biotechnology complex. But Cobb also asks tough questions regarding our propensity to meddle with nature, including the 2018 CRISPR babies scandal, reaching the unsettling conclusion that “dreams and nightmares must go hand in hand”.

This is the classic personal account of the discovery of the structure of DNA. I read it as an early college assignment, but now find it rich in history, biology, and insight. Watson described himself as an ornithology undergraduate who avoided chemistry and physics courses in spite of a desire to do science—a common sentiment. He unfolds in frank detail how the world of science worked, and sometimes didn’t work, early post-WWII. We learn as much about bond angles and hydration as we do about laboratory politics and personality quirks beneath the effort to puzzle out the structure and function of DNA. The epilogue pays tribute to less well-known collaborators, especially Rosalind Franklin, sometimes dismissed as uncooperative, but recognized here for her essential contributions and competence as a scientist.

I enjoyed Perfected because it was a very, very soft and gentle take on dystopia where young girls are genetically engineered in labs and trained with special traits as young girls only to be sold to wealthy families as pets. They’re treated as puppies who are dressed in fancy clothes, paraded through events, sat on pretty couches and chairs, and very, very few make it through without being manipulated and used in worse ways. When she falls in love with her owner’s son, and he starts to fall for her, bad things happen. I love putting twists on dystopian worlds so this one was a brilliant, unusual concept that brought such a unique look into the genre and its possibilities and gave me permission to do the same.

The concept of this story is amazing, especially at a time when they are “bringing back” different species. I am often amazed at what scientists have been able to accomplish in real life, and it’s even more fun to read about it in fiction. 

Another thing that I loved about this story is how it shows that nature cannot be contained. We can manipulate it, but we’d better not make too many assumptions about how things will progress because nature has its own way of doing things.

The characters were also great in both the book and the movie.

I’m a geek for a good undercover story because of the constant underlying tension. Place that undercover story in an alternate world, and you’ve got my attention! Leviathan takes place in Scott Westerfeld's fabulous re-imagining of the events surrounding WWI. It’s a world where the secrets of DNA were discovered far earlier and put to use as natural “machinery.”

Our star is Deryn Sharp, one of my favorite middle-grade heroines. She’s a commoner disguised as a boy in the British Air Service. She's a brilliant airman, brave and fearless and clever… and living in constant fear someone will discover her secret. Even so, she faces conflict head-on and is quick on her feet.

She fights on the side of the Darwinists, using extraordinary genetically altered creatures, against the Clankers and their steampunk-style weaponry. They’re no match for Deryn, though, as she saves the day again and again with her mind… show more.

A planet in its equivalent of the stone age is passing through a galactic debris field. An alien stargazer realizes that sooner or later some object will strike the planet and destroy it. The only hope of survival his species has is to leave the planet before that happens. But the concept is a mere abstraction to his people, the equivalent of a Neanderthal saying “we need to travel to the moon,” and the task is further complicated by the fact that their technology is biological in nature, focused on the manipulation of living tissue. It is hard to imagine how such technology could ever produce a spaceship. 

The novel--structured as a series of novellas-- follows the development of a fascinating alien species from its primitive roots to an age of high technology, each chapter focusing on a different time period. Always the stargazer’s warning is proclaimed by a few… show more.