100 Books Like The Mutant Project

A Crack in Creation was the first mainstream book that conveyed the extraordinary potential and ethical peril of the new genome editing technology, CRISPR. And who better to write it than the scientist who co-developed the “genetic scissors”, Professor Jennifer Doudna (who won the Nobel Prize three years later).

The book is also notable for the candid manner in which Doudna discusses her own nightmares about the potential misuse of CRISPR – fears that erupted one year later in the ‘CRISPR babies’ scandal.

Somewhat paradoxically, this treatise against genetic enhancement starts with the case of a deaf couple who want to have a deaf child.

This is a case I often discuss in exploring the difference between disease, disability, and diversity. Following on from this case description, Sandel asks, “Is it wrong to make a child deaf by design?” And what if the desired trait was not deafness but height, athletic prowess, health, or intelligence, and the aim was to gain a competitive advantage?

Would your answer be the same? In the pages that follow, Sandel builds a case against “reengineering our nature” grounded in an ethic of giftedness (i.e., a reverence for life as a gift).

He eschews the drive to mastery and insists that “[t]o appreciate children as gifts is to accept them as they come, not as objects of our design, or products of our will, or instruments of our… show more.

This work of fiction highlights the potential dangers of genetic engineering.

It invites the reader to imagine a world in which it is possible to genetically modify early-stage human embryos, making changes that will determine the life-trajectory of the newborn.

In this world, Dr. Saul Kramer, a geneticist, and the head of a successful IVF clinic, uses CRISPR technology not to correct disease-causing genes in unhealthy embryos, but rather to insert a gene for a fatal genetic disease into healthy embryos.

Children born of these genetically modified embryos die in the first year of life. Notably, this is not a whodunnit, but a morality tale framed around the question of whether Dr. Kramer is a murderer. 

Many assert that “science is outpacing ethics.”

In my book I argue that this claim is false and disingenuous. Consider this one example. Forty years ago, Glover anticipated the myriad ways in which genetic and neuro technologies might “change the central framework of human life.”

In this prescient book, Glover anticipates the use of genetic engineering and advocates caution as well as gradualness. Avoiding the risk of irreversible disaster is a priority. Glover outlines the drawbacks of centralized decision-making as well as the problems with piecemeal, short-term decision-making.

He enjoins us to reflect on what sort of people there should be and what sort of future we should try to bring about. My own work focuses on what kind of world we want to live in and, as such, we are kindred spirits.

When I read Michael Crichton’s Next, my first thought was that we’re entering a dangerous time with our ability to manipulate the genomes of many different species.

The central message is about the possible negative ramifications of manipulating the DNA of humans and other animal species and even the creation of transspecies. Crichton leads us through diverse stories of corporate greed to the life and death struggles of others just wanting a cure for cancer.

Crichton does a masterful job of tying the different agendas into a compelling, interwoven narrative. 

I originally picked up this book because I really like the author. Seanan McGuire never disappoints. Parasite is part one of a series, and is a completely fresh take on what some people might call zombies (although there is a lot of room for speculation there). The characters were compelling, and the plot kept me reading when I should have been doing countless other things. I love everything I’ve ever read by McGuire (alternate pen name Mira Grant), and this book was no different.

This one is totally different than the others on my list, but when I was diving into these related genres and finding myself more and more inspired by them, it was always a surprise and a treat to find a book that just completely defied all genre expectations. The book blends Sci-Fi with Fantasy, something I’ve always enjoyed if done well, and something that made me think maybe I could try my hand at this. I was never that great in science or math, even though I tried, but the idea that we could mix Sci-Fi with Fantasy, now that was intriguing. And throw in a little unexpected romance and I think you have a really well-rounded adventure. Humans are the root cause of the ending of the human race, so obviously humans have to undo what they’ve done, but your average person is just trying to survive the fallout.

I enjoyed Perfected because it was a very, very soft and gentle take on dystopia where young girls are genetically engineered in labs and trained with special traits as young girls only to be sold to wealthy families as pets. They’re treated as puppies who are dressed in fancy clothes, paraded through events, sat on pretty couches and chairs, and very, very few make it through without being manipulated and used in worse ways. When she falls in love with her owner’s son, and he starts to fall for her, bad things happen. I love putting twists on dystopian worlds so this one was a brilliant, unusual concept that brought such a unique look into the genre and its possibilities and gave me permission to do the same.

The concept of this story is amazing, especially at a time when they are “bringing back” different species. I am often amazed at what scientists have been able to accomplish in real life, and it’s even more fun to read about it in fiction. 

Another thing that I loved about this story is how it shows that nature cannot be contained. We can manipulate it, but we’d better not make too many assumptions about how things will progress because nature has its own way of doing things.

The characters were also great in both the book and the movie.

Butler is known for bringing a black, feminist, and queer perspective to science fiction, a genre of futuristic and outer-space storytelling that traditionally features white male protagonists.

But what really captivates me about this book, which is set in a post-apocalyptic future where human survivors are mated with their alien rescuers (really!), is the way it asks icky-yet-intensely-meaningful questions. What does it mean to “be human” in a future of genetic hybridity and gender fluidity? What does it mean to love a partner or children whose genetics and culture are radically different from your own? When is violence futile, and when is it the only way to be heard?

I’m pretty much obsessed with this book, and I promise that any reader who has thought deeply about what it means to be really different will love it too.