Why read Understanding the Control of Metabolism?

Book cover of Understanding the Control of Metabolism

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Book by Fell, David

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Why read it?

1 author picked Understanding the Control of Metabolism as one of their favorite books. Why do they recommend it?

Charlie Hodgman

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This book turns on its head what I was taught about what controls metabolite flow through a pathway. It covers highly remarkable discoveries concerning which steps control changes in metabolite levels: those at the end rather than the start of pathways. This is amazing because it explains why decades of effort by bioengineers to overproduce particular metabolites was unsuccessful.

In response to a request from such a project, I explained how to block the inhibitory regulation by the early pathway step but added that, according to metabolic control theory, this would leave the end-product levels unchanged. I was correct on…

From Charlie's list on The best books at the intersection of Bioinformatics and Systems Biology.